Abstract:Aim To investigate the relationship between urinary albumin creatinine ratio (UACR) and brachial-ankle pulse wave velocity (baPWV) in type 2 diabetes patients. Methods A total of 800 type 2 diabetes mellitus (T2DM) patients were enrolled in a cross sectional study. baPWV, lipid, renal function, UACR, fasting C-peptide, glycosylated hemoglobin, serum calcium, serum phosphorus and parathyroid hormone were measured. The correlations between baPWV and parameters were analyzed. Results With the increased level of age, baPWV increased (P<0.001). UACR levels were classified into three groups. The mean baPWV in group of UACR>300 mg/g (1958.10±530.76 cm/s) was higher than group of UACR<30 mg/g (1609.86±310.98 cm/s) and UACR 30~300 mg/g (1659.88±354.27 cm/s), and the differences were statistically significant (both P<0.005). Pearson analysis showed that age, systolic blood pressure, pulse pressure difference, serum urea nitrogen and UACR were positively correlated with baPWV (r=0.554, 0.393, 0.440, 0.158, 0.300, all P<0.05), while serum albumin, estimated glomerular filtration rate, phosphorus and multiplication of calcium and phosphorus were negtively correlated with baPWV (r=-0.195,-0.261, -0.203, -0.176, all P<0.05). In the multiple linear step-down regression model with baPWV as the dependent variable, age, systolic blood pressure and UACR were positively associated with baPWV (β=0.488, 0.266, 0.143, t=14.55, 8.12, 4.47, all P<0.001), while phosphorus was inversely associated with baPWV (β=-0.083, t=-2.57, P<0.05). Conclusion BaPWV was independently associated with age, systolic blood pressure, UACR and serum phosphorus.