Abstract:Aim To discuss the relationship between H-type hypertension and renal insufficiency in patients with coronary atherosclerotic heart disease (CHD) and chronic heart failure (CHF). Methods 100 CHD patients with both hypertension and CHF were chosen in our hospital from January 2011 to July 2013. Left ventricular ejection fraction (LVEF) was measured with echocardiography and estimated glomerular filtration rate (eGFR) was calculated with the simplified modification of diet in renal disease (MDRD) equation in all these patients. Brain natriuretic peptide (BNP) and plasma homocysteine (Hcy) were tested when they were first enrolled. According to Hcy level, all the patients were divided into two different groups: H-type hypertension group (Hcy≥10 μmol/L, n59) and simple hypertension group (Hcy<10 μmol/L, n41). Age, gender, body mass index (BMI), LVEF, BNP, eGFR and classification of cardiac function were compared between the two groups. Then all patients’eGFR were evaluated and classified into different stages according to chronic kidney disease (CKD) progression, from CKD1 to CKD4, and the percentage of H-type hypertension, LVEF, BNP, Hcy level were all compared between the four different groups. Finally in order to identify the risk factor of renal insufficiency in patients with CHD and CHF, Logistic regression analysis modal was established with the dependent variable-eGFR, and the independent variables, like age, gender, BMI, smoking, diabetes, H-type hypertension.