妊娠期高血压综合征患者颈动脉血管功能及血脂水平的变化
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Changes of Carotid Artery Funtion and Blood Lipid Levels in Patients with Pregnancy-induced Hypertension
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    目的 探讨妊娠期高血压综合征(PIH)患者颈动脉血管功能及血脂代谢的特点。方法 选择来我院就诊的98名孕妇作为研究对象,将48例PIH孕妇作为PIH组,并将年龄及孕周匹配的50名正常孕妇作为对照组。于妊娠晚期和产后6个月分别采用超声射频信号血管分析技术对孕妇颈动脉内膜中膜厚度(IMT)、血管弹性指标脉搏波传导速度(PWV)、等容收缩期到射血期转折点压(PT1)、动脉增强压(AP)及动脉压增强指数(AIx)进行检测,同时测量其血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白A1(ApoA1)、载脂蛋白B100(ApoB100)。结果 与对照组比较,妊娠晚期PIH组孕妇IMT增厚,PWV、PT1、AP、AIx均升高,TC、TG、LDLC及ApoB100升高, HDLC及ApoA1/ApoB100降低(P均<0.05);产后6个月两组比较,PIH组TG升高(P<0.05),ApoA1/ApoB100降低(P<0.05),其余各指标差异均无统计学意义(P均>0.05)。孕妇IMT与其血压及血脂代谢各指标的相关性分析结果显示,孕妇IMT与各血压值及血脂代谢各指标(除外ApoB100)之间均具有密切的相关性(P均<0.05)。结论 PIH患者妊娠晚期颈动脉血管结构和弹性发生改变,血脂代谢紊乱。产后6个月其颈动脉血管结构和弹性恢复正常,血脂代谢恢复到大致正常水平。血脂代谢异常导致血管弹性和功能的改变可能是导致PIH发生的原因。

    Abstract:

    Aim To research carotid intima-media thickness (IMT) and elasticity and blood lipid levels in patients with pregnancy-induced hypertension (PIH). Methods 98 women with pregnancy were divided into 2 groups: 48 patients with pregnancy induced hypertension for research group (PIH group), 50 women with pregnancy that age and gestational weeks were matched for control group. To evaluate carotid IMT, pulse wave velocity (PWV), pressure at T1 (PT1), augmented pressure (AP) and augmentation index (AIx) in patients ultrasound radio-frequency data (RF-data) technology was used. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDLC), low density lipoprotein (LDLC ), apolipoprotein A1 (ApoA1) and apolipoprotein B100 (ApoB100) were detected and compared in each group. Results Compared with the control group, pregnant women’s test value of IMT and PWV, PT1, AP and AIx of PIH group increased, TC, TG, LDLC, ApoB100 increased, and HDLC, ApoA1/ApoB100 decreased in late pregnancy. The differences were statistically significant (all P<0.05). After 6 months postpartum, TRIG increased and ApoA1/ApoB100 decreased compared with the control group (all P<0.05). The differences of other indexes had no statistical significance (P>0.05). The correlation between IMT and blood pressure and blood lipid metabolism shows,the IMT and the blood pressure and blood lipid metabolism of each index (exception of ApoB100) all have close correlation (P< 0.05). Conclusions PIH women had change of the carotid arterial structure and elasticity and blood lipid metabolism disorder in late pregnancy. But after 6 months postpartum,the carotid structure and elasticity recovered. Lipid metabolism returned to almost normal level. Blood lipid metabolic abnormalities caused vascular elasticity and the function of change may be the cause of PIH occurred.

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李一春.妊娠期高血压综合征患者颈动脉血管功能及血脂水平的变化[J].中国动脉硬化杂志,2014,22(07):723~726.

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  • 收稿日期:2013-11-27
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