Aim To investigate the relationship between the concentration of plasma lipocalin-2 （LCN2） and common carotid artery intima-medial thickness （CCA-IMT） in newly diagnosed type 2 diabetic patients. Method 166 newly diagnosed type 2 diabetic patients （age 35～70, duration≤1 year） and 65 healthy people were recruited. CCA-IMT was detected by high-resolution ultrasonography, plasma concentration of LCN2 was measured by enzyme-linked immunosorbent assay. Results Adjusting for age and sex, type 2 diabetics’ plasma concentration of LCN2 was significantly higher than that in the healthy group （P<0.05）. According to the three tilter of plasma concentration of LCN2, the highest concentration group’s CCA-IMT was significantly higher than that in the lowest concentration group （P0.026）.