Aim To explore the relevant factors of the ischemic stroke patients with cerebral microbleeds, and to provide reference for clinical diagnosis. Methods 142 ischemic stroke patients were collected from the second hospital of Lanzhou university with taking examination of MRI from March 2013 till 2014. Clinical data and the MRI examination results of all the patients were recorded and all the patients were divided into the group of ischemic stroke with cerebral microbleeds and the group of simple ischemic stroke, according to the results of SWI. Possible relevant factors of cerebral microbleeds about ischemic stroke patients were analyzed by logistic regression analysis. Two groups of patients were analyzed by Mann-Whitney U test to explore the relation between CMB and leukoaraiosis. Results Ischemic stroke with cerebral microbleeds was associated with hypertension and leukoaraiosis（P<0.05）. It was not associated with sex, age, diabetes mellitus, hyperlipidemia and the history of taking anti-coagulants or anti-platelet drugs（P>0.05）. Compared with the group of simple ischemic stroke, the degree of leukoaraiosis was more serious in the group of ischemic stroke with cerebral microbleeds （P<0.05）. Conclusion Hypertension and leukoaraiosis were the relevant factors of ischemic stroke with cerebral microbleeds. Among ischemic stroke patients, the degree of leukoaraiosis in patients with cerebral microbleeds was more serious.