Abstract:Aim To investigate the relationship between rate-pressure product and brachial-ankle pulse wave velocity (BaPWV) in middle-aged and older women. Methods A total of 5852 participants was selected with stratified random sampling from the 101510 workers of Tangshan Kailuan company who received the health examination. Among them 2043 women with integral data were recruited into the survey. The observation population was divided into four groups according to the rate-pressure product collected during 2010~2011 health examinations: quartile 1 (the rate-pressure product<7500.00), quartile 2 (7500.00≤the rate-pressure product<8624.00), quartile 3 (8624.00≤the rate-pressure product<10121.00), quartile 4 (the rate-pressure product≥10121.00). Multivariate logistic regression analysis was used to analyze the the influence of the rate-pressure product on BaPWV. Results (1) There were 2043 women with an average age of 52.2±9.7 years old. Their mean of BaPWV was 1488.9 cm/s. (2)The mean of BaPWV for the above quartiles of the rate-pressure product were 1266.0, 1377.3, 1525.6, 1786.7 cm/s, respectively and the detection rates of BaPWV≥1400 cm/s were 19.5%, 37.2%, 59.6%, 84.3%, respectively. (3) Multiple logistic regression analysis showed that after adjusting for age and other risk factors, compared with quartile 1, the risk of increasing BaPWV was increased in quartile 2, 3 and 4 of the rate-pressure product and the OR values were 1.66 (95%CI 1.16~2.37), 3.18 (95%CI 2.19~4.62) and 7.30 (95%CI 4.67~11.42), respectively. Conclusion The rate-pressure product is positively associated with increasing BaPWV in middle-aged and older women.