Obesity is a common disease defined as a state of excess body fat accumulation which stems from energy imbalance. Obesity is closely associated with varied metabolism syndromes, such as atherosclerosis, insulin resistance and dyslipidemia. Obesity per se is a chronic inflammatory disease in adipose tissue, accompanied with activation of cellular inflammatory signals, release of inflammatory cytokines and infiltration of immune cells. The inflammatory mediators from adipose tissue may affect other tissues or organs via circulation system, thus induce the genesis of related metabolism syndrome. Therefore the understanding of metaflammation and its mechanisms contributes to research on obesity and the related diseases. The new therapies and targets aiming at metaflammation in obesity are the new prospects to treat obesity and related metabolic diseases.