Aim To explore the association between circulating high sensitivity C-reactive protein （hs-CRP）,interleukin-6 （IL-6） and white matter lesion （WML）. Methods In 378 patients with asymptomatic lacunar infarction or dizziness,consecutively admitted to the Department of Neurology of the First People's Hospital of Anqing from Dec.2011 to May.2014，the data including their hs-CRP and IL-6 levels and brain MRI scanning were retrospectively analyzed. Among them 166 patients were finally diagnosed to have WML. The severity of WML in the white matter was classified into three groups according to Fazekas' standard: WML0 level group （72 cases）,WML1 level group （55 cases） and WML2 level group （39 cases）. The differences were compared between the three groups in age,gender,history of smoking,history of coronary heart disease,blood cholesterol and low density lipoprotein levels,systolic blood pressure,diastolic blood pressure,blood glucose,hs-CRP and IL-6. Results In the WML2 level group the patient's age,history of coronary heart disease,systolic blood pressure,diastolic blood pressure,total cholesterol,hs-CRP and IL-6 were significantly increased,compared with WML0 level group,there were significant differences （P＜0.05）. Compared with WML1 level group,the patient's age,history of coronary heart disease,systolic blood pressure,diastolic blood pressure,CRP and IL-6 in the WML2 level group had statistically significant difference （P＜0.05）,implying that age,history of coronary heart disease,systolic blood pressure,diastolic blood pressure and total cholesterol were all the risk factors for WML. Advanced analysis using binary Logistic regression demonstrated that statistical difference still existed between the three groups in hs-CRP and IL-6 level even if rejecting the factors of age,history of coronary artery disease,cholesterol and blood pressure. Multivariate regression analysis showed that hs-CRP was correlated with the degree of WML （OR＝1.480,95%CI was 1.030～1.850,P0.032） and IL-6 was correlated with the degree of WML （OR＝1.395,95%CI was 1.002～1.607,P0.040）. Conclusion Hs-CRP,IL-6 levels and the severity of WML are positively correlated.