The lectin-like oxidized low density lipoprotein receptor-1 （LOX-1） on the vascular endothelial cell is the main receptor for oxidized low density lipoprotein. The extracellular domain of LOX-1 on the cell surface can undergo proteolysis and be released as soluble LOX-1 （sLOX-1）. The level of sLOX-1 in serum elevates for relative disease with atherosclerosis and vascular endothelium injuries, which suggests sLOX-1 is a promising biomarker. In the present paper the cardiovascular related diseases regarding sLOX-1 as biomarker were firstly reviewed in detail.