Neurite outgrowth inhibitor （Nogo）, also known as reticulon-4 （RTN-4）, is mainly located in the endoplasmic reticulum, its gene encoding three kinds of products, namely Nogo-A, Nogo-B and Nogo-C. Nogo-A and Nogo-C are mainly involved in the inhibition of axonal regeneration after central nervous system injury. Because of Nogo-B’s being widely distributed, it not only affects the central nervous system regeneration, but also participates in the process of atherosclerosis, vascular endothelial regeneration, repair of the tissue damage and cell apoptosis. Nogo-B receptor （NgBR） is a specific receptor of Nogo-B N-terminal, and it can interact with Nogo-B or play a biological role independently. In recent years, it has been found that NgBR can be involved in the metabolism of cholesterol, the synthesis of alcohol, and the promotion of angiogenesis and the chemotaxis of endothelial cells. The biological function of NgBR is being paid more and more attention, and the research of NgBR in recent years is reviewed.