Aim To investigate the correlation between health-related quality life （HRQL） and risk factors in non-diabetic premature coronary heart disease （CHD） man.Methods 215 non-diabetic man patients （age fewer than 50） were selected from cardiology department （Sun Yat-sen Memorial Hospital of Sun Yat-sen University） from January 2012 to January 2015. All subjects were diagnosed by coronary angiography and divided into two groups according to the percentage of coronary artery stenosis as follows: 104 cases with coronary artery stenosis above 50% （age 43.04±4.69, CHD group） and 111 cases with coronary artery stenosis less than 50% （age 42.92±4.30, Healthy control group）. Clinical data and health-related quality information were collected and analyzed by SPSS 18.0.Results 1） Hypertension, hyperlipidemia, smoking, family history, diastolic blood pressure and systolic blood pressure were significantly higher in the CHD group than that of the healthy control group （P<0.05） 2） The proportion of low education, stress pressure and excess fatigue were significantly higher in the CHD group than that of the healthy control group （P<0.05） 3） Smoking, hypertension, high pressure and excess fatigue significantly increased the incidence of coronary heart disease in non-diabetic man patients after adjusting the relative risk factors, which included smoking, drinking, hypertension, hyperlipidemia, hyperuricemia, the family history of coronary heart disease, low education, stress pressure and excess fatigue. The odds ratio （OR） and 95% CI for smoking, hypertension, stress pressure and excess fatigue were 5.005 （2.096, 11.954）, 3.704 （1.466, 9.355）, 2.635 （1.309, 5.302）, 2.594 （1.192, 5.648） respectively （P<0.05）.Conclusion Our data suggest that smoking, hypertension, stress pressure and excess fatigue are the risk factors of premature CHD in non-diabetic man, and smoking is the most significant risk factor in this study.