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原发性高血压患者Th17细胞及其相关细胞因子与颈动脉内膜中膜厚度的相关性
作者:
作者单位:

(1.山东省医学科学院基础医学研究所心脑血管病防治研究中心,山东省济南市 250062;2.济南大学 山东省医学科学院医学与生命科学学院,山东省济南市 250022;3.山东省地方病防治研究所,山东省济南市 250022)

作者简介:

孙晓林,硕士研究生,主要从事高血压及动脉硬化研究,E-mail为sunxiaolin1@126.com。

基金项目:

国家自然科学基金项目(81470489)；山东省自然科学基金项目(ZR2014HM098、ZR2012HL46、ZR2014HQ042)；山东省医药卫生科技发展计划项目(2014WS0312、2014WS0316、2013WS0364、2013WS0176)


Th17 Cell and Th17-associated Cytokines Related to Carotid Artery Intima-media Thickness in Essential Hypertension Patient
Author:
Affiliation:

1.Center of Cardio- and Cerebral Vascular Disease Prevention and Treatment, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China;2.School of Medicine and Life Sciences, University of Jinan & Shandong Academy of Medical Sciences, Jinan, Shandong 250022, China;3.Shandong Institute of Endemic Diseases Control and Prevention, Jinan, Shandong 250022, China)

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    摘要:

    目的 探讨原发性高血压患者Th17细胞及其相关细胞因子与颈动脉内膜中膜厚度(IMT)的相关性。方法 选取原发性高血压患者206例,行颈动脉超声检查,根据颈动脉IMT三分位数分为高三分位组、中三分位组和低三分位组。检测并比较3组患者外周血Th17细胞频率及其相关细胞因子白细胞介素17(IL-17)、IL-6和肿瘤坏死因子α(TNF-α)水平。分析各因素与颈动脉IMT的相关性。结果 高三分位组、中三分位组、低三分位组外周血Th17细胞频率分别为1.45%±0.30%、1.19%±0.29%、1.03%±0.28%,IL-17分别为24.03±6.38、18.85±6.23、15.84±5.36 ng/L,IL-6分别为87.09±13.65、75.26±17.21、68.40±16.15 ng/L,TNF-α分别为77.24±14.91、65.39±17.62、60.30±17.51 ng/L。高三分位组Th17细胞频率、IL-17、IL-6、TNF-α均高于中三分位组和低三分位组(P<0.05)；中三分位组Th17细胞频率、IL-17、IL-6均高于低三分位组(P<0.05)。Pearson相关分析显示,Th17细胞频率、IL-17、IL-6、TNF-α与颈动脉IMT呈显著正相关(P<0.01)。多元线性逐步回归分析显示,Th17细胞频率、IL-17、IL-6和TNF-α是影响颈动脉IMT的主要危险因素。结论 原发性高血压患者Th17细胞及其相关细胞因子的血清水平与颈动脉IMT密切相关。

    Abstract:

    Aim To investigate the correlation of Th17 cells and Th17-associated cytokines with carotid artery intima-media thickness(IMT) in essential hypertensive patients. Methods After carotid ultrasound examination, 206 essential hypertensive patients were categorized into three groups by the tertiles of IMT, namely, high tertile group, middle tertile group and low tertile group. Peripheral blood Th17 cell frequency and serum levels of Th17-associated cytokines interleukin-17(IL-17), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were tested and compared in three groups. The correlation between the various factors and carotid IMT was analyzed. Results In high tertile group, middle group and low group, respectively, Th17 cell frequency was 1.45%±0.30%, 1.19%±0.29%, 1.03%±0.28%; IL-17 was 24.03±6.38, 18.85±6.23, 15.84±5.36 ng/L; IL-6 was 87.09±13.65, 75.26±17.21, 68.40±16.15 ng/L; TNF-α was 77.24±14.91, 65.39±17.62, 60.30±17.51 ng/L. Th17 cell frequency, IL-17, IL-6, and TNF-α in high tertile group were higher than those in middle tertile group and low tertile group(P<0.05). Th17 cell frequency, IL-17, and IL-6 in middle tertile group were higher than those in low tertile group(P<0.05). Pearson correlation analysis showed that Th17 cell frequency, IL-17, IL-6, and TNF-α were positively correlated with carotid IMT(P<0.01). Multivariate linear stepwise regression analysis showed that Th17 cell frequency, IL-17, IL-6, and TNF-α were main risk factors for carotid IMT. Conclusion Th17 cell and Th17-associated cytokines are closely related to carotid artery IMT in patient with essential hypertension.

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孙晓林,刘振东,王舒健,赵颖馨,张华,刁玉涛,栾萌,王秀红.原发性高血压患者Th17细胞及其相关细胞因子与颈动脉内膜中膜厚度的相关性[J].中国动脉硬化杂志,2016,24(2):155~158.

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  • 收稿日期:2014-12-31
  • 最后修改日期:2015-02-20
  • 在线发布日期: 2016-06-30

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