Bone morphogenetic proteins-4 (BMP-4), a member of the transforming growth factor β (TGF-β) superfamily, is a multi-functional growth factor that plays key roles in embryonic development, angiogenesis, cell proliferation and differentiation, skeletal formation, ectopic osteogenesis, fracture repair, and et al. Vascular calcification(VC) is considered as an actively regulated and complex process, similar to osteogenesis. The transdifferentiation process of vascular smooth muscle cells(VSMC) to the osteogenic phenotype plays a crucial role in the formation of VC. In recent years, researches have shown that BMP-4 may be implicated in the formation and progress of VC, but the specific mechanism has not yet been elucidated. The relationship between BMP-4 and VC are reviewed in this paper.