Aim To analyze the correlation between plasma fibrinogen degradation product (FDP), D-dimer and short term prognosis in patients with acute coronary syndrome (ACS). Methods 154 patients with ACS were selected and followed up for 3 months. According to major adverse cardiovascular event (MACE) in the follow-up period, the patients were divided into two groups:MACE group (75 cases) and non-MACE group (79 cases). The levels of FDP, D-dimer, prothrombin time (PT), international normalized ratio (INR) and platelet count (PLT) were detected and compared between the two groups. The risk factors of influencing MACE occurrence in patients with ACS were confirmed by multivariate Logistic regression analysis. The best predictive values of FDP and D-dimer for MACE occurrence in patients with ACS were evaluated by receiver operating characteristic (ROC) curve. Results Compared with non-MACE group, plasma levels of FDP and D-dimer were increased in MACE group (P＜0.05), but there were no differences in the levels of PLT, PT and INR between the two groups (P＞0.05). Plasma FDP and D-dimer were the risk factors of MACE occurrence in patients with ACS (P＜0.05). The area under ROC curve (AUC) of FDP and D-dimer predicting MACE occurrence in patients with ACS were 0.682 and 0.796, respectively (P＝0.028, P＝0.014). Taking FDP≥2.54 μg/L and D-dimer≥0.61 mg/L as the cutoff point, AUC was 0.857, the sensitivity was 67.9%, the specificity was 76.5%, and the accuracy was 69.1% for determining MACE occurrence. Conclusion The plasma levels of FDP and D-dimer in ACS patients are strongly correlated with the occurrence of MACE.