Atherosclerosis (As) is a chronic inflammatory disease characterized by dyslipidemia, monocyte-macrophage infiltration, endothelial injury, and thrombosis. Recently, Wnt family plays an important role in the initiation and progression of atherosclerotic plaque. Wnt family is a cysteine-rich secreted glycoprotein which involved in the regulation of various biological processes through both canonical and non-canonical pathways. Previous studies suggest that Wnt family and its signaling pathways regulate the interaction between reverse cholesterol transport (RCT) and inflammatory responses, and play an important role in triggering atherosclerotic lesions. This review summarized the mechanisms of RCT and inflammatory response via Wnt family and its signaling pathway, which might provide novel diagnostic and therapeutic strategies for prevention and treatment of As.