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真核翻译起始因子2α在动脉粥样硬化等增殖性疾病中的研究进展
作者:
作者单位:

(1.南华大学附属南华医院临床研究所,湖南省衡阳市 421002;2.南华大学衡阳医学院应用解剖与生殖医学研究所, 湖南省衡阳市 421001;3.南方医科大学基础医学院人体解剖学教研室,广东省广州市 510515)

作者简介:

郭林亚,硕士研究生,研究方向为肺动脉高压发病机制,E-mail为2214765239@qq.com。通信作者李严兵,博士,教授,硕士研究生导师,研究方向为数字骨科解剖基础、数字血管解剖基础,E-mail为hnlybup001@163.com。通信作者王爱平,博士,副教授,研究方向为肺动脉高压发病机制,E-mail为waiping2011@163.com。

基金项目:

国家自然科学基金青年项目(81600040)；中国博士后基金面上项目(2017M622589)；湖南省自然科学基金青年项目(2017JJ3279)；湖南省大学生创新性课题(352)


Research advances on eukaryotic translation initiation factor 2α in proliferative diseases such asatherosclerosis
Author:
Affiliation:

1.Institute of Clinical Medicine, Nanhua Affiliated Hospital, University of South China, Hengyang, Hunan 421002, China;2.Institute of Applied Anatomy and Reproductive Medicine, School of Medicine, University of South China, Hengyang, Hunan 421001, China;3.Department of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China)

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    摘要:

    真核翻译起始因子2α(eIF2α)是真核翻译起始因子2的一种调节亚基,是催化蛋白质合成起始的关键蛋白。以往研究证实,磷酸化的eIF2α对蛋白质的合成能够起到负反馈调控的作用；最近研究发现,磷酸化的eIF2α还能特异性激活某些mRNA的翻译以合成特定蛋白质来调节靶基因的表达,进而促进疾病的发生发展。研究发现,eIF2α在动脉粥样硬化、肺动脉高压、肿瘤等增殖性疾病中差异表达,这些证据提示eIF2α可能在人类心血管病和肿瘤等增殖性疾病中发挥重要的作用。因此,进一步探讨eIF2α在增殖性疾病中的作用及机制,对于人类心血管病和肿瘤等增殖性疾病的防治具有重要意义。

    Abstract:

    Eukaryotic translation initiation factor 2α (eIF2α) is a regulatory subunit of eukaryotic translation initiation factor 2 and is the key protein to catalyze the initiation of protein synthesis. Previous studies have confirmed that phosphorylated eIF2α can play a negative feedback regulation on protein synthesis. Recent studies have found that phosphorylated eIF2α can also specifically activate the translation of certain mRNA to synthesize specific proteins to regulate the expression of target genes, thereby promoting the occurrence and development of diseases. It has been found that eIF2α is differentially expressed in proliferative diseases such as atherosclerosis, pulmonary arterial hypertension and tumors. These evidences suggest that eIF2α may play an important role in human proliferative diseases such as cardiovascular diseases and tumors. Therefore, further exploring the role and mechanism of eIF2α in proliferative diseases is of great significance for the prevention and treatment of proliferative diseases such as cardiovascular diseases and tumors.

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引用本文

郭林亚,阳芳,李严兵,王爱平.真核翻译起始因子2α在动脉粥样硬化等增殖性疾病中的研究进展[J].中国动脉硬化杂志,2019,27(2):169~174.

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  • 收稿日期:2018-07-10
  • 最后修改日期:2018-08-08
  • 在线发布日期: 2019-01-21

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