Coronary heart disease (CHD) and its complications are the most important risk factors for human mortality, so the research on the prevention and treatment of CHD has been paid more and more attention in academic circles.A large number of studies have shown that the main pathological process of CHD is the destruction of lipid metabolism balance and the activation of inflammatory response. It will provide an effective method for clinical diagnosis of CHD if we can summarize the changes of related protein expression in the course of CHD. The discovery of new biomarkers is of great significance for the prevention and treatment of CHD. In recent years, a large number of biomarkers which are closely related to cardiovascular diseases have been discovered. Novel lipid-related biomarkers such as proprotein convertase subtilisin/kexin 9 and sortilin participates in the occurrence and development of CHD by regulating the level of oxidized low density lipoprotein cholesterol. Inflammatory markers such as soluble urokinase plasminogen activated receptor affect the pathophysiological process of CHD through a variety of pathways. Therefore, this article mainly reviews the research progress of blood lipids, inflammation and other related new biomarkers in CHD, in order to provide a new reference and ideas for the clinical diagnosis, treatment and prognosis evaluation of cardiovascular disease.