低密度脂蛋白亚型与冠状动脉病变程度的关系

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低密度脂蛋白亚型与冠状动脉病变程度的关系
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作者:
                        刘广彬刘广彬
扬州大学附属医院 扬州市第一人民医院,江苏省扬州市 225001
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夏光伟夏光伟
扬州大学附属医院 扬州市第一人民医院,江苏省扬州市 225001
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龚开政龚开政
扬州大学附属医院 扬州市第一人民医院,江苏省扬州市 225001
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张振刚张振刚
扬州大学附属医院 扬州市第一人民医院,江苏省扬州市 225001
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黄华康黄华康
扬州大学附属医院 扬州市第一人民医院,江苏省扬州市 225001
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作者单位:(扬州大学附属医院 扬州市第一人民医院,江苏省扬州市 225001)
作者简介:刘广彬,硕士,主治医师,研究方向为冠心病基础与临床,E-mail为18994872327@189.cn。
通讯作者:
基金项目:中华医学会心血管分会领航基金项目(LHJJ20140321)

Relationship between low density lipoprotein subfractions and severity of coronary artery disease

Author:

LIU Guangbin
LIU Guangbin
Department of Cardiology, Affiliated Hospital of Yangzhou University, the First Peoples Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China
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XIA Guangwei
XIA Guangwei
Department of Cardiology, Affiliated Hospital of Yangzhou University, the First Peoples Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China
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GONG Kaizheng
GONG Kaizheng
Department of Cardiology, Affiliated Hospital of Yangzhou University, the First Peoples Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China
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ZHANG Zhengang
ZHANG Zhengang
Department of Cardiology, Affiliated Hospital of Yangzhou University, the First Peoples Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China
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HUANG Huakang
HUANG Huakang
Department of Cardiology, Affiliated Hospital of Yangzhou University, the First Peoples Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China
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Affiliation:

Department of Cardiology, Affiliated Hospital of Yangzhou University, the First People's Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China)

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摘要:

目的评价Lipoprint Systerm检测的低密度脂蛋白亚型与冠状动脉病变程度的相关性。方法回顾性搜集冠心病患者139例,所有患者应用Lipoprint Systerm对低密度脂蛋白亚型进行定量分析,并行冠状动脉造影检查,计算病变血管支数及Gensini评分,比较血管三支病变组与简单病变组、Gensini评分高分患者与低分患者的临床特征及脂蛋白亚型的差异,通过Logistic回归分析低密度脂蛋白亚型与冠状动脉病变程度的相关性。结果与简单病变组比较,三支病变组低密度脂蛋白(LDL3)、小而密低密度脂蛋白(sdLDL)、sdLDL浓度百分比升高(P＜0.05),LDL1~2浓度百分比降低(P＜0.05)。三支病变组高血压、糖尿病比例高(P＜0.05)。Logistic回归分析显示高血压、糖尿病、糖化血红蛋白(HbA1c)、LDL3、sdLDL、sdLDL浓度百分比与三支血管病变呈正相关,LDL1~2浓度百分比与三支血管病变呈负相关。与Gensini低分组比较,Gensini高分组极低密度脂蛋白(VLDL)、总胆固醇(TC)、非高密度脂蛋白(nonHDL)、甘油三酯(TG)、LDL3、LDL4、LDL6、sdLDL、sdLDL浓度百分比升高(P＜0.05),LDL1~2浓度百分比降低(P＜0.05)。Logistic回归分析显示高血压、HbA1c、LDL6、LDL7、sdLDL、sdLDL浓度百分比与Gensini评分呈正相关,LDL1~2浓度百分比与Gensini评分呈负相关。结论 sdLDL及sdLDL浓度百分比与冠状动脉病变程度正相关,LDL1~2浓度百分比与冠状动脉病变程度负相关。

关键词:低密度脂蛋白亚型;小而密低密度脂蛋白;冠状动脉疾病

Abstract:

Aim To evaluate the correlation between the low-density lipoprotein subfractions detected by the Lipoprint method and the degree of coronary artery disease. Methods 139 patients with coronary heart disease were retrospectively analyzed, all patients undergo the quantitative analysis of low-density lipoprotein subfractions with Lipoprint systerm, coronary angiography, calculation of diseased vessel count and Gensini score, comparison of the clinical characteristics and lipoprotein subfractions of patients between three-vessel disease group and simple disease group as well as high scores in Gensini scores and low scores. Logistic regression was used to evaluate the correlation between low density lipoprotein subfractions and the severity of coronary lesions. Results Compared with the simple lesion group, the concentration oflowdensity lipoprotein(LDL3), small and dense low-density lipoprotein(sdLDL), and sdLDL percentage in the three-vessel disease group increased (P＜0.05), and the concentration percentage of LDL1~2 decreased (P＜0.05). The proportion of hypertension and diabetes in the three-vessel disease group was high (P＜0.05). Logistic regression analysis showed that hypertension, diabetes, hemoglobin A1c(HbA1c), LDL3, sdLDL and the concentration percentages of sdLDL were positively correlated with three-vessel disease, and the concentration percentage of LDL1~2 was negatively correlated with three-vessel disease. Compared with the Gensini Score(GS) low group, very low density lipoprotein (VLDL), total cholesteral(TC), non high denseity lipoprotein(nonHDL), triglyceride (TG), LDL3, LDL4, LDL6, sdLDL, and the concentration percentage of sdLDL increased in GS high group(P＜0.05), and the concentration percentage of LDL1~2 decreased (P＜0.05). Logistic regression analysis showed that hypertension, HbA1c, LDL6, LDL7, sdLDL and the concentration percentages of sdLDL were positively correlated with GS, and the concentration percentage of LDL1~2 was negatively correlated with Gensini score. Conclusion sdLDL and the concentration percentage of sdLDL was positively correlated with the degree of coronary artery disease. The concentration percentage of LDL1~2 was negatively correlated with the degree of coronary artery disease.

Key words:low density lipoprotein subfractions; small and dense low-density lipoprotein; coronary artery disease

参考文献

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引用本文

刘广彬,夏光伟,龚开政,张振刚,黄华康.低密度脂蛋白亚型与冠状动脉病变程度的关系[J].中国动脉硬化杂志,2019,27(12):1053~1057.

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收稿日期:2019-03-21
最后修改日期:2019-08-10
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在线发布日期: 2019-12-18

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