FGF-21与心血管疾病发生发展的关系
作者:
作者单位:

(1.山西医科大学第二临床医学院,山西省太原市 030001;2.山西医科大学第二医院心血管内科,山西省太原市 030001)

作者简介:

高宏伟,硕士研究生,研究方向为冠心病,E-mail 为 419970223@qq.com。通信作者高奋,博士,副主任医师,研究方向为冠心病基础与临床,E-mail 为gao55555@sina.com。

基金项目:

山西省自然科学基金资助项目(201801D121321)


Relationship between FGF-21 and the development of cardiovascular disease
Author:
Affiliation:

1.The Second Clinical College of Shanxi Medical University, Taiyuan, Shanxi 030001, China;2.Cardiovascular Department,the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China)

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • | |
    摘要:

    成纤维细胞生长因子21(FGF-21)是一种主要调节糖脂代谢的调节因子,其在糖尿病改善作用上有很大成果,但其在有益于心血管疾病发生发展研究中的作用存在很多分歧,本文着重介绍FGF-21分别在冠心病、心律失常及心力衰竭、心肌病的发生发展中的作用,为FGF-21在心血管疾病方面的研究提供新方向。

    Abstract:

    Fibroblast growth factor-21(FGF-21) is a major regulator of glycolipid metabolism, which has great results in the improvement of diabetes, but there are many differences in the research on the beneficial effects of many cardiovascular diseases. This paper introduces the role of FGF-21 in the development of coronary heart disease, arrhythmia and heart failure, and provides a new direction for the study of FGF-21 in cardiovascular diseases.

    参考文献
    [1] Itoh N.Hormone-like (endocrine) Fgfs:their evolutionary history and roles in development, metabolism and disease.Cell and Tissue Research, 0,2(1):1-11.
    [2] 肖卫晋, 李国华, 屈顺林, 等.成纤维细胞生长因子21心肌保护作用的研究进展.中国动脉硬化杂志, 7,5(5):527-530.
    [3] Nishimura T, Nakatake Y, Konishi M, et al.Identification of a novel FGF, FGF-21, preferentially expressed in the liver.Biochim Biophys Acta, 0,2(1):203-206.
    [4] Johnson CL, Weston JY, Chadi SA, et al.Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice.Gastroenterology, 9,7(5):1795-1804.
    [5] Inagaki T, Dutchak P, Zhao G, et al.Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21.Cell Metabolism, 7,5(6):415-425.
    [6] Xiaoshan M, Jennifer W, Sheree J, et al.Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions.J Biol Chem, 8,3(38):14678-14688.
    [7] Kim KH, Jeong YT, Oh H, et al.Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine.Nat Med, 3,9(1):83-92.
    [8] Xu P, Ye X, Zhang Y, et al.Long-acting hypoglycemic effects of PEG lated FGF21 and insulin glargine in mice with type 1 diabetes.J Diabetes Complications, 5,9(1):5-12.
    [9] Li H, Wu G, Fang Q, et al.Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat.Nat Commun, 8,9(1):272.
    [10] 孙梦丽.成纤维细胞生长因子21与糖尿病性大血管病变.中国动脉硬化杂志, 7,5(1):95-98.
    [11] Kharitonenkov A, Wroblewski VJ, Koester A, et al.The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.Endocrinology, 7,8(2):774-781.
    [12] Shen Y, Zhang X, Xu Y, et al.Serum FGF21 is associated with future cardiovascular events in patients with coronary artery disease.Cardiology, 8,9(4):212.
    [13] Lee CH, Woo YC, Chow WS, et al.Role of circulating fibroblast growth factor 21 measurement in primary prevention of coronary heart disease among chinese patients with type 2 diabetes mellitus.J Am Heart Assoc, 7,6(6):e005344.
    [14] Lin Z, Wu Z, Yin X, et al.Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.PLoS One, 0,5(12):15534.
    [15] Zhang C, Huang Z, Gu J.Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2 dependent signalling pathway.Diabetologia, 5,8(8):1937-1948.
    [16] Cao F, Wang S, Cao X, et al.Fibroblast growth factor 21 attenuates calcification of vascular smooth muscle cells in vitro.J Pharm Pharmacol, 7,9(12):1802-1816.
    [17] Shi Y, Wang S, Peng H, et al.Fibroblast growth factor 21 attenuates vascular calcification by alleviating endoplasmic reticulum stress mediated apoptosis in rats.Int J Biol Sci, 9,5(1):138-147.
    [18] Maida A, Zota A, Vegiopoulos A, et al.Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.J Nutr Biochem, 8,7(7):189-196.
    [19] Kliewer SA, Mangelsdorf DJ.Fibroblast growth factor 21:from pharmacology to physiology.Am J Clin Nutr, 0,1(1):254.
    [20] Lin XL, He XL, Zeng JF, et al.FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARγ-LXRα pathway in THP1 macrophage-derived foam cells.DNA Cell Biol, 4,3(8):514-521.
    [21] Kiel C, Serrano L.Challenges ahead in signal transduction:MAPK as an example.Curr Opin Biotechnol, 2,3(3):305-314.
    [22] Zhu W, Wang C, Liu L, et al.Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo.Can J Physiol Pharmacol, 4,2(11):927.
    [23] B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk:the CHARGE-AF consortium of community-based cohort studies.Europace, 4,6(10):1426-1433.
    [24] 李伟章, 谷凌云, 邹建伟, 等.血清FGF21水平与心房颤动风险研究.中国现代医学杂志, 8,8(8):90-93.
    [25] Hui TH, Mcclelland RL, Allison MA, et al.The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation:the multi-ethnic study of atherosclerosis.Atherosclerosis, 8,9(2):86-91.
    [26] Wang R, Yi X, Li X, et al.Fibroblast growth factor-21 is positively associated with atrial fibrosis in atrial fibrillation patients with rheumatic heart disease.Int J Clin Exp Pathol, 5,8(11):14901.
    [27] Planavila A, Redondo I, Hondares E, et al.Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.Nat Commun, 3,4(3):201.
    [28] Cong WT, Ling J, Tian HS, et al.Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury.Can J Physiol Pharmacol, 3,1(11):973.
    [29] Chou RH, Huang PH, Hsu CY, et al.Circulating fibroblast growth factor 21 is associated with diastolic dysfunction in heart failure patients with preserved ejection fraction.Sci Rep, 6,6(9):1-10.
    [30] Planavila A, Iglesias R, Giralt M.Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.Cardiovasc Res, 1,0(2):276-284.
    [31] Planavila A, Redondo I, Hondares E, et al.Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.Nat Commun, 3,4(3):1-12.
    [32] Wu F, Wang B, Zhang S, et al.FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice.Clin Sci(Lond), 7,1(5):1877-1893.
    引证文献
引用本文

高宏伟,王远,冯高洁,代佩,高奋. FGF-21与心血管疾病发生发展的关系[J].中国动脉硬化杂志,2020,28(3):262~267.

复制
分享
文章指标
  • 点击次数:788
  • 下载次数: 939
历史
  • 收稿日期:2019-05-09
  • 最后修改日期:2019-06-09
  • 在线发布日期: 2020-01-20