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高脂血症、单核细胞亚型与动脉粥样硬化
作者:
作者单位:

(1.天然药物活性物质与功能国家重点实验室 新药作用机制研究与药效学评价北京重点实验室 中国医学科学院 北京协和医学院药物研究所, 北京市 100050;2.浙江大学医学院附属杭州市第一人民医院药学部, 浙江省杭州市 310006;3.美国贝勒医学院医学部心血管研究室,德克萨斯州休斯顿市 77030;4.内蒙古医科大学基础医学院 药物筛选中心与新药安全评价和研究中心,内蒙古呼和浩特市 010110)

作者简介:

彭雪英,博士,药师,研究方向为脂质代谢与动脉粥样硬化,E-mail为pengxy1991@126.com。通信作者朱海波,博士,研究员,教授,研究方向为动脉粥样硬化相关疾病新药靶的发现和药物研发,E-mail为zhuhaibo@imm.ac.cn。

基金项目:

国家自然科学基金重大研究计划培育项目(91539126)；中国医学科学院医学与健康科技创新工程重大协同创新项目(2016-I2M-1-009)；国家科技重大专项-重大新药创制 (2018ZX09711001-003-011)；国家自然科学基金青年科学基金项目(81703511)


Hyperlipidemia, monocyte subtypes and atherosclerosis
Author:
  • PENG Xueying 1,2

    PENG Xueying

    State Key Laboratory for Bioactive Substances and Functions of Natural Medicines & Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study & Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Department of Clinical Pharmacy, Affiliated Hangzhou First Peoples Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China
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  • WU Huaizhu 3

    WU Huaizhu

    Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, United States
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  • WANG Minjie 1,4

    WANG Minjie

    State Key Laboratory for Bioactive Substances and Functions of Natural Medicines & Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study & Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Center for Drug Screening and Center for New Drug Safety Evaluation and Research, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China
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  • ZHU Haibo 1

    ZHU Haibo

    State Key Laboratory for Bioactive Substances and Functions of Natural Medicines & Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study & Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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Affiliation:

1.State Key Laboratory for Bioactive Substances and Functions of Natural Medicines & Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study & Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;2.Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China;3.Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, United States;4.Center for Drug Screening and Center for New Drug Safety Evaluation and Research, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, China)

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    摘要:

    单核细胞是天然免疫的重要组成部分,在血管炎症和动脉粥样硬化(As)中发挥重要作用。高脂血症可加速心血管疾病,尤其是As的进展。高脂血症时,循环单核细胞能吸收脂质,形成泡沫状单核细胞,改变表型,可能有助于动脉粥样硬化的发展。长期以来,单核细胞及其不同亚型对高脂血症的响应和对As的作用一直是人们研究的热点。本文探讨了人和小鼠的单核细胞亚型特点,高脂血症对单核细胞的影响,以及单核细胞对As的作用等,重点介绍了单核细胞通过脂质吞噬、泡沫细胞形成、巡逻以及迁移入斑块等途径影响As进程的研究进展。

    Abstract:

    Monocytes are important mediators of the innate immunity and play crucial roles in various inflammatory diseases, including vascular inflammation and atherosclerosis (As). Hyperlipidemia can accelerate cardiovascular disease progression, especially As. Under hyperlipidemia, circulating monocytes can take up lipids, become foamy monocytes and change phenotypes, which may contribute to development of As. For a long time, the response of monocytes and their different subtypes to hyperlipidemia and the effect on As have been the focus of research. This paper discusses the characteristics of monocyte subtypes in human and mice, the effects of hyperlipidemia on monocytes, and the effects of monocytes on As, and focuses on the research progress of monocytes affecting As process through lipid phagocytosis, foam cell formation, patrolling and migration into plaques.

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引用本文

彭雪英,武怀珠,王敏杰,朱海波.高脂血症、单核细胞亚型与动脉粥样硬化[J].中国动脉硬化杂志,2020,28(9):815~822.

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  • 收稿日期:2019-08-10
  • 最后修改日期:2020-01-07
  • 在线发布日期: 2020-10-28

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