Aim To analyze the efficacy and safety of bioabsorbable polymer-coated drug-eluting stents in patients with coronary heart disease and diabetes mellitus. Methods The study searched database both at home and abroad, and retrieved the clinical randomized controlled trial (RCT) of comparison of bioabsorbable polymer-coated drug-eluting stent (BP-DES) and durable polymer-coated drug-eluting stent (DP-DES) in patients with coronary heart disease and diabetes mellitus. The efficacy and safety were evaluated by target lesion failure rate, target vessel revascularization rate, target lesion revascularization rate and cardiogenic mortality rate. Results A total of 14 RCT were included, of which 3 855 patients were treated with BP-DES and 2 916 patients with DP-DES, with a mean follow-up of 2.9 years. The overall target lesion failure rate of BP-DES versus DP-DES was 13.5% versus 12.8% (RR:1.7,5% CI:0.88～1.29, P=0.50). The overall cardiac mortality rate of BP-DES versus DP-DES was 6.2% versus 5.4% (RR:1.0,5%CI:0.90～1.34, P=0.35), and the overall target lesion and target vessel revascularization rates were not statistically different. There were no statistically significant differences in subgroup analysis according to follow-up time. Conclusion In patients with coronary heart disease and diabetes, BP-DES has a similar safety and efficacy profile to DP-DES.