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冠心病合并高血压患者血清C1q肿瘤坏死因子相关蛋白3及心肌缺血总负荷与心肌缺血的相关性
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(皖北煤电集团总医院心血管内科,安徽省宿州市 234000)

作者简介:

李为,主治医师,研究方向为心血管内科,E-mail为liweilwww@126.com。通信作者朱坤,副主任医师,研究方向为冠心病,E-mail为rukuig@126.com。


Correlation between serum C1q tumor necrosis factor related protein 3, total myocardial ischemia burden and myocardial ischemia in patients with coronary heart disease and hypertension
Author:
Affiliation:

Department of Cardiovascular Medicine, Wanbei Coal and Electricity Group General Hospital, Suzhou, Anhui 234000, China)

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    摘要:

    目的 观察冠心病(CHD)合并高血压患者血清C1q肿瘤坏死因子相关蛋白3(CTRP3)和心肌缺血总负荷(TIB)与心肌缺血的相关性。方法 回顾性分析本院2018年1月—12月期间收治的CHD合并高血压患者的临床资料,将其中未发生心肌缺血的32例患者纳入非心肌缺血组,发生心肌缺血的80例患者纳入心肌缺血组。对比两组受试者血清CTRP3水平和TIB,并分析CTRP3与TIB之间的相关性。分析CHD合并高血压患者发生心肌缺血的影响因素及CTRP3、TIB对CHD合并高血压患者发生心肌缺血的预测价值。结果 与非心肌缺血组相比,心肌缺血组患者CTRP3较低,TIB较高,差异均有统计学意义(P＜0.05)。经双变量Spearman相关性检验,血清CTRP3水平与TIB呈负相关(r＝－0.665,P＜0.001)。线性回归分析显示,CTRP3、TIB均可能是导致CHD合并高血压患者发生心肌缺血的影响因素(P＜0.05)。ROC曲线分析得知,CTRP3、TIB预测CHD合并高血压患者发生心肌缺血的曲线下面积分别为0.942、0.913,具有较高的预测价值。结论 血清CTRP3和TIB与CHD合并高血压患者发生心肌缺血密切相关,对CHD合并高血压患者发生心肌缺血具有较高的预测价值。

    Abstract:

    Aim To observe the correlation between serum C1q tumor necrosis factor related protein 3 (CTRP3), total myocardial ischemia burden (TIB) and myocardial ischemia in patients with coronary heart disease (CHD) and hypertension. Methods The clinical data of CHD patients with hypertension admitted to our hospital from January 2018 to December 2018 were retrospectively analyzed. Among them, 32 patients without myocardial ischemia were included in the non-myocardial ischemia group, and 80 patients with myocardial ischemia were included in the myocardial ischemia group. The level of serum CTRP3 and TIB were compared between the two groups, and the correlation between CTRP3 and TIB was analyzed. The influencing factors of myocardial ischemia in patients with CHD and hypertension, and the predictive value of CTRP3 and TIB for myocardial ischemia in patients with CHD and hypertension were analyzed. Results Compared with non-myocardial ischemia group, CTRP3 was lower and TIB was higher in myocardial ischemia group, and the differences were statistically significant (P＜0.05). After bivariate Spearman correlation test, serum CTRP3 level was negatively correlated with TIB (r＝－0.665, P＜0.001). Linear regression analysis showed that CTRP3 and TIB might be the influencing factors of myocardial ischemia in patients with CHD and hypertension (P＜0.05). ROC curve analysis showed that the area under curve of CTRP3 and TIB in predicting myocardial ischemia in patients with CHD and hypertension was 0.942 and 0.913 respectively, which had higher predictive value. ConclusionSerum CTRP3 and TIB are closely related to myocardial ischemia in CHD patients with hypertension, which have high predictive value for myocardial ischemia in CHD patients with hypertension.

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李为,朱坤,郑玉水,陈振岭,方勇.冠心病合并高血压患者血清C1q肿瘤坏死因子相关蛋白3及心肌缺血总负荷与心肌缺血的相关性[J].中国动脉硬化杂志,2021,29(6):529~533.

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  • 收稿日期:2020-05-27
  • 最后修改日期:2020-09-04
  • 在线发布日期: 2021-06-11

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