Atherosclerosis is the main cause of cardio-cerebrovascular related diseases. Among the influencing factors of atherosclerosis, angiogenesis is one of the main causes of plaque rupture and various complications. Hypoxia, inflammation and growth factor-related factors can cause angiogenesis in plaques and lead to atherosclerosis. This article reviews the related factors affecting angiogenesis and their mechanism, in order to provide new ideas and intervention targets for the prevention and treatment of atherosclerosis.