Aim To evaluate the associations between single nucleotide polymorphisms (SNP) in lipoprotein(a) gene (LPA) and coronary heart disease (CHD). Methods PubMed, Embase, Web of Science, Cochran, CNKI and Wanfang database were searched to collect the studies focusing on the association of LPA gene rs10455872 and/or rs3798220 with CHD from the inception date of each database to June 0,1. Two researchers independently screened literatures, extracted information and assessed the risk of bias. Newcastle-Ottawa score (NOS) was used to evaluate the quality of each study. The heterogeneity among studies was assessed by I² and Cochran Q test. Random effect model was used to estimate odds ratio (OR) and 95% confidence interval (95%CI) when the heterogeneity was significant (I²≥50% and P＜0.05). The network Meta-analysis was applied to compare the effects of different SNP. Publication bias was analyzed using funnel plot and Egger’s test. RevMan 5.3 and R 4.0.5 were used for data analysis. P＜0.05 was considered as statistical significance. Results Of the 15 studies that were included in the analysis, 9 were analyzed for rs10455872 and 15 for rs3798220. The results of Meta-analysis demonstrated that the rs10455872_G and rs3798220_C alleles were significantly associated with CHD (rs10455872_G:OR 1.9,5%CI 1.10～1.30; rs3798220_C:OR 1.9,5%CI 1.27～2.00). In the dominant model, carriers of rs10455872_G allele had a 21% higher risk of CHD than participants with AA(OR 1.1,5% CI 1.11～1.32), and carriers of rs3798220_C allele had a 59% higher risk of CHD than participants with CC(OR 1.9,5%CI 1.26～2.02). Network Meta-analysis indicated that the carriers of rs3798220_C allele had higher risk of CHD. Conclusion LPA gene SNP were associated with CHD, individuals carrying the risk allele should pay more attention to prevent cardiovascular diseases.