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冠心病患者小而密低密度脂蛋白胆固醇与血浆致动脉硬化指数的相关性
作者:
作者单位:

(承德医学院附属医院心脏内科,河北省承德市 067000)

作者简介:

马珂琳,硕士,研究方向为心脏内科,E-mail为makelinn@163.com。通信作者张英,主任医师,教授,主要研究方向为冠心病及介入治疗,E-mail为cyfyzy@126.com。

基金项目:

河北省科学技术厅指令性计划项目(17277769D)


Correlation between small and dense low density lipoprotein cholesterol and atherogenic index of plasma in patients with coronary heart disease
Author:
Affiliation:

Department of Cardiology, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, China)

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    摘要:

    目的 探讨冠心病(CHD)患者小而密低密度脂蛋白胆固醇(sdLDLC)与血浆致动脉硬化指数(AIP)的关系。方法 回顾性收集本院2019年9月—2020年6月因胸痛、胸闷入院,疑似CHD行冠状动脉造影检查的525例患者为研究对象,根据冠状动脉造影结果分为CHD组(n＝422)和非CHD组(n＝103)。同时又按照AIP三分位数分为3组:AIP≤－0.056组(n＝176),－0.056＜AIP＜0.208组(n＝175),AIP≥0.208组(n＝174)。测定各血脂指标并计算AIP。比较CHD组和非CHD组的sdLDLC和AIP水平。分析AIP的影响因素和CHD的危险因素。结果 CHD组sdLDLC、AIP、低密度脂蛋白(LDL)亚型LDL3、LDL4显著高于非CHD组,LDL1、高密度脂蛋白胆固醇显著低于非CHD组(P＜0.05)。随着AIP增加,sdLDLC、LDL4显著升高,LDL1、LDL2显著降低(P＜0.001)。多元线性回归分析显示,sdLDLC、高血压史是AIP的独立影响因素(P＜0.05)。多因素Logistic回归分析显示,sdLDLC、AIP是CHD的独立危险因素(P＜0.05)。结论 CHD患者sdLDLC与AIP呈显著正相关,sdLDLC、AIP是CHD发生的独立危险因素。

    Abstract:

    Aim To investigate the relationship between small and dense low density lipoprotein cholesterol (sdLDLC) and atherogenic index of plasma (AIP) in patients with coronary heart disease (CHD). Methods A total of 525 patients admitted to our hospital due to chest pain and chest tightness from September 2019 to June 2020 and suspected CHD underwent coronary angiography were retrospectively collected as the research subjects. According to coronary angiography results, they were divided into CHD group (n＝422) and non-CHD group (n＝103). At the same time, they were divided into three groups according to AIP tertiles:AIP≤－0.056 group (n＝176), －0.056＜AIP＜0.208 group (n＝175), AIP≥0.208 group (n＝174). Each lipid index was measured and AIP was calculated. sdLDLC and AIP levels were compared between CHD group and non-CHD group. Influencing factors for AIP and risk factors for CHD were analyzed. Results The sdLDLC, AIP, low density lipoprotein (LDL) subtype LDL3, LDL4 in CHD group were significantly higher than those in non-CHD group, and the LDL1, high density lipoprotein cholesterol in CHD group were significantly lower than those in non-CHD group (P＜0.05). With the increase of AIP, sdLDLC and LDL4 increased significantly, while LDL1 and LDL2 decreased significantly (P＜0.001). Multiple linear regression analysis showed that sdLDLC and history of hypertension were independent influencing factors of AIP (P＜0.05). Multivariate Logistic regression analysis showed that sdLDLC and AIP were independent risk factors for CHD (P＜0.05). Conclusion There is a significant positive correlation between sdLDLC and AIP in CHD patients, and sdLDLC and AIP are independent risk factors for CHD.

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马珂琳,连欢,王亚柱,孙历贤,刘超,张英.冠心病患者小而密低密度脂蛋白胆固醇与血浆致动脉硬化指数的相关性[J].中国动脉硬化杂志,2022,30(6):490~494.

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  • 收稿日期:2021-05-02
  • 最后修改日期:2021-06-16
  • 在线发布日期: 2022-05-10

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