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首页 > 按月查看>2023年第3月 >190-198. DOI:10.20039/j.cnki.1007-3949.2023.03.002
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斑块侵蚀在急性冠状动脉综合征中的作用及机制研究进展
作者:
作者单位:

(1.首都医科大学基础医学院生理学与病理生理学系;2.重塑相关心血管疾病教育部重点实验室;3.代谢紊乱相关疾病北京市重点实验室,北京市100069)

作者简介:

陈芸儿,主要研究方向为内皮功能紊乱与血管损伤性疾病,E-mail:17301191597@163.com。通信作者曲爱娟,教授,博士研究生导师,主要研究方向为低氧与重塑心血管相关疾病,E-mail:aijuanqu@ccmu.edu.cn。

基金项目:

北京市自然科学基金B类重点项目(KZ202010025032)；北京市属高校高水平教师队伍建设支持计划(CIT&TCD20190332)资助


Research progress on the role and mechanism of plaque erosion in acute coronary syndrome
Author:
Affiliation:

1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University;2.Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education;3.Key Laboratory of Metabolic Disorders, Beijing 100069, China)

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    摘要:

    急性冠状动脉综合征是世界范围内发病率和死亡率较高的一组临床综合征。目前,越来越多的证据表明,带有完整纤维帽的斑块侵蚀是导致急性冠状动脉综合征的主要原因之一。基础实验已经揭示了斑块侵蚀的独特分子特征,已有研究表明,血流紊乱会引起内皮细胞损伤,从而导致基底膜丧失其完整性以及内皮细胞脱落,继而形成中性粒细胞胞外陷阱和血栓,导致斑块侵蚀。文章将讨论动脉粥样硬化斑块侵蚀的分子特征以及对斑块侵蚀患者未来精准医疗所需的转化研究。

    Abstract:

    Acute coronary syndrome (ACS) is a group of clinical syndromes with high morbidity and mortality worldwide. Increasing evidence suggest that plaque erosion with an intact fibrous cap is one of the major causes responsible for ACS. Basic experiments have shed light on the unique molecular characteristics of plaque erosion. It has been indicated that plaque erosion starts with the changes of blood flow disturbance-induced endothelial cell damage, resulting in loss of basement membrane integrity and endothelial cell desquamation, with consequent formation of neutrophil extracellular traps and thrombosis. This review will discuss the molecular characteristics of atherosclerotic plaque erosion and translational research needed for future precision medicine in patients with plaque erosion.

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陈芸儿,张琦,于宝琪,曲爱娟.斑块侵蚀在急性冠状动脉综合征中的作用及机制研究进展[J].中国动脉硬化杂志,2023,31(3):190~198.

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  • 收稿日期:2022-05-07
  • 最后修改日期:2022-08-14
  • 在线发布日期: 2023-03-24

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