2025年4月24日 周四
首页 > 按月查看>2023年第5月 >432-440. DOI:10.20039/j.cnki.1007 3949.2023.05.010
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脂肪组织纤维化的研究进展
作者:
作者单位:

(海军军医大学药学系临床药学教研室,上海市200433)

作者简介:

陈缘静,硕士研究生,研究方向为药学,E-mail:1040445984@qq.com。通信作者孙旸,副教授,硕士研究生导师,研究方向为药理学,E-mail:DawnySun@126.com。

基金项目:

国家自然科学基金项目(82073907)；上海市“科技创新行动计划”(20ZR1470100和20S11902700)


The research progress of adipose tissue fibrosis
Author:
Affiliation:

Department of Clinical Pharmacology, School of Pharmacy, Naval Medical University, Shanghai 200433, China)

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    摘要:

    脂肪组织纤维化是指脂肪组织的细胞外基质发生不当重塑并造成异常沉积。脂肪组织纤维化作为脂肪组织功能障碍的重要标志,与肥胖、胰岛素抵抗等代谢功能障碍密切相关。而逆转脂肪组织纤维化,有助于恢复脂肪组织功能、改善胰岛素抵抗,进而改善肥胖等患者代谢异常情况。文章总结了脂肪组织纤维化病理机制的最新研究进展以及逆转脂肪组织纤维化的潜在药物靶点,以期为深入了解这一病理过程,研发治疗药物提供方向。

    Abstract:

    Adipose tissue fibrosis is caused by improper remodeling of the extracellular matrix, which leads to abnormal deposition in adipose tissue. As the hallmark of adipose tissue dysfunction, adipose tissue fibrosis has a close relationship with metabolic dysfunction such as obesity and insulin resistance. Therefore, reversing adipose tissue fibrosis can restore the function of adipose tissue, enhance the sensibility of insulin and then improve patients' metabolic abnormalities such as obesity. This review summarizes the latest research progress in the pathological mechanism of adipose tissue fibrosis and the potential drug targets for reversing adipose tissue fibrosis, in order to provide a greater insight into this pathological process and provide the direction of drug development.

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陈缘静,陈弋,刘霞,孙旸.脂肪组织纤维化的研究进展[J].中国动脉硬化杂志,2023,31(5):432~440.

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  • 收稿日期:2022-08-19
  • 最后修改日期:2023-01-21
  • 在线发布日期: 2023-05-19

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