BASP1功能与人类疾病的研究进展

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BASP1功能与人类疾病的研究进展
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                        伍晓棋1,2伍晓棋
南华大学衡阳医学院基础医学院细胞与遗传研究所,湖南省衡阳市 421001;南华大学衡阳医学院附属长沙中心医院,湖南省长沙市 410004
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王丹玲1,2王丹玲
南华大学衡阳医学院基础医学院细胞与遗传研究所,湖南省衡阳市 421001;南华大学衡阳医学院附属长沙中心医院,湖南省长沙市 410004
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作者单位:(1.南华大学衡阳医学院基础医学院细胞与遗传研究所,湖南省衡阳市 421001;2.南华大学衡阳医学院附属长沙中心医院,湖南省长沙市 410004)
作者简介:伍晓棋,硕士研究生,研究方向为帕金森氏病的病理机制研究,E-mail:18988544202@163.com。
通讯作者:
基金项目:湖南省科技创新重点工程项目(2021SK1014)

Advances in the functions of the BASP1 protein in human diseases

Author:

WU Xiaoqi ^{^1,2}
WU Xiaoqi
Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;Changsha Central Hospital Affiliated to Hengyang Medical College, University of South China, Changsha, Hunan 410004, China
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WANG Danling ^{^1,2}
WANG Danling
Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;Changsha Central Hospital Affiliated to Hengyang Medical College, University of South China, Changsha, Hunan 410004, China
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Affiliation:

1.Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;2.Changsha Central Hospital Affiliated to Hengyang Medical College, University of South China, Changsha, Hunan 410004, China)

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脑膜黏附信号蛋白1(BASP1)最初在大鼠的大脑中被发现,广泛表达于大脑、心脏、口腔、皮肤、胃、肾脏等多个人体器官。BASP1蛋白序列在进化上保守,以固有无序蛋白(IDP)的形式参与了生物体内细胞信号传递、细胞迁移、细胞凋亡、基因转录等进程,与神经发育、肾脏发育、生殖细胞形成等一系列病理生理过程密切相关,在糖脂代谢疾病和肿瘤类疾病中BASP1发挥了极其重要的作用,被认为是极具潜力的疾病治疗靶点及分子诊断标志物。

关键词:脑膜黏附信号蛋白1;固有无序蛋白;糖脂代谢疾病;肿瘤

Abstract:

Brain abundant membrane attached signal protein 1 (BASP1) was first discovered in the rat brain and is primarily enriched in brain, heart, mouth, skin, stomach, kidneys and many other human organs. The BASP1 protein is evolutionarily conserved. It participates in cellular biological processes such as cell signaling, cell migration, apoptosis, and gene transcription as an inherently disordered protein (IDP), and is involved in a series of pathophysiological processes such as neural development, kidney development, and germ cell formation. BASP1 plays a very important function in glucose, lipid metabolism diseases and tumor diseases, and is considered to be a potential disease treatment target and molecular diagnostic marker.

Key words:brain abundant membrane attached signal protein 1; intrinsically disordered protein; glycolipid metabolic diseases; tumor

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伍晓棋,王丹玲. BASP1功能与人类疾病的研究进展[J].中国动脉硬化杂志,2024,32(5):444~450.

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收稿日期:2023-12-18
最后修改日期:2024-02-14
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在线发布日期: 2024-05-09

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