Atherosclerosis (As) is a chronic inflammatory disease caused by lipid deposition. Panvascular diseases, which are mainly caused by As, have gradually attracted the attention of many scholars, and their main pathological features are vascular lesions. Vitamin D plays an important role in anti-As in panvascular diseases. It is involved in the regulation of renin-angiotensin system (RAS), endothelial cell injury, immune response, neutrophil extracellular traps (NET) regulation, apoptosis and autophagy, and is a new target in panvascular diseases research. Traditional Chinese Medicine (TCM) has certain advantages in the prevention and treatment of panvascular diseases. Among them, single herbs, active ingredients and compound prescriptions can regulate vitamin D-related metabolism, and have unique scientific value for the prevention and treatment of As. This article mainly discusses the role of vitamin D in multiple pathological links of panvascular diseases and related Chinese medicine interventions, aiming to provide effective ideas for the prevention and treatment of panvascular diseases from the perspective of vitamin D.