Aim To investigate the effects of Gubu decoction combined with intraluminal reconstruction on bipedal vibration sensation threshold and microcirculation in patients with lower extremity arteriosclerotic occlusive disease (LEAOD). Methods A total of 152 patients who came to Lishui Gentral Hospital for LEAOD treatment from April 2021 to April 2023 were divided into the observation group (intraluminal reconstruction+Gubu decoction, 76 cases) and the control group (intraluminal reconstruction, 76 cases) by random number table method, and the traditional Chinese medicine (TCM) syndrome scores, clinical efficacy, microcirculation indicators and bifoot vibration sensation threshold of the two groups were compared. Results After treatment, the scores of TCM syndromes such as limb pain, limb numbness, intermittent claudication, and limb fear of cold decreased after treatment in both groups,and the decrease of observation group was more obvious (P＜0.05). The clinical effect of observation group (96.05%) was significantly higher than that of control group (84.21%) (P＜0.05). After treatment, the flow state integral, tube loop integral and periloop integral decreased, and the apical vessel diameter increased in both groups, and the changes of various indexes in the observation group were more significant (P＜0.05). After treatment, the threshold of sensation in both groups decreased, and the observation group was significantly lower (P＜0.05). Conclusion Gubu decoction combined with intraluminal reconstruction can effectively reduce the foot sensation threshold and improve the microcirculation of affected limbs in LEAOD patients.