Aim To investigate the effect of combined enhanced exteral counterpulsation (EECP) therapy on blood lipids, inflammatory status, and cardiorespiratory function in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), under the premise of standardized drug treatment. Methods A total of 93 patients diagnosed with CHD and undergoing PCI surgery at Cardiovascular Department, the Second Hospital of Shanxi Medical University were selected for screening from June 2022 to December 2023. According to the patients' treatment intention, they were randomly divided into control group and EECP group. The control group received simple drug treatment, while the EECP group received combined EECP treatment for 3 months on the basis of drug treatment. Blood lipids, monocyte to high density lipoprotein cholesterol ratio (MHR), neutrophil to lymphocyte ratio (NLR), and exercise endurance indicators were recorded and compared before and after treatment. Results After treatment, the patients in EECP group showed a 19.6% decrease in total cholesterol (TC), a 27.0% decrease in triglyceride (TG), a 25.0% decrease in low density lipoprotein cholesterol (LDLC), a 25.4% decrease in MHR, a 37.2% decrease in NLR, and a 6.7% increase in maximum exercise time, with statistical significance (P＜0.05). The treatment effect was better than that of the control group. Conclusion On the basis of standardized drug treatment, the combination of EECP treatment in patients with CHD after PCI can effectively reduce blood lipid levels, improve systemic inflammation, promote the improvement of motor function, and improve patients' quality of life.